Differentiation between Single- and Double-Stranded DNA through Local Capacitance Measurements

作者：Estrada Vargas Arturo; Jambrec Daliborka; Kayran Yasin Ugur; Kuznetsov Volodymyr; Schuhmann Wolfgang^*

来源：ChemElectroChem, 2016, 3(6): 855-857.

DOI：10.1002/celc.201600075

• AC-SECM
• DNA hybridization
• influence diagram
• local capacitance
• SEIM

Local differentiation of single-stranded (ss) and double-stranded (ds) DNA in microarrays by using electrochemical techniques has gained increasing interest. We propose a method for distinguishing areas on gold electrodes modified with ssDNA and dsDNA based on the difference in their local capacitance. The local capacitance is visualized by means of scanning electrochemical impedance microscopy and alternating-current scanning electrochemical microscopy.

• 出版日期2016-6