Limited cytoprotective effects of Amifostine in high-dose radioactive iodine 131-treated well-differentiated thyroid cancer patients: Analysis of quantitative salivary scan

作者：Kim Seong Jang; Choi Hee Young; Kim In Ju^*; Kim Yong Ki; Jun Sungmin; Nam Hyun Yul; Kim Ju Sung

来源：Thyroid, 2008, 18(3): 325-331.

DOI：10.1089/thy.2007.0191

Purpose: The aim of present study was to investigate the cytoprotective effect of amifostine on salivary glands in I-131-treated differentiated thyroid cancer (DTC) patients using serial quantitative analysis of salivary gland scans.
Methods: Serial quantitative salivary scintigraphies were performed in 80 newly diagnosed DTC patients (9 men, 71 women; mean age, 43.2 years old; range, 21-58 years old). Forty-two patients were assigned randomly to the amifostine treatment group, which received 300mg/m(2) amifostine intravenously before I-131 administration.
Results: In both amifostine-treated and nontreated groups statistically significant declines of functional parameters after I-131 treatment were revealed by quantitative salivary scintigraphy in DTC patients. Amifostine pretreatment did not prevent the parenchymal damage to major salivary gland function after I-131 treatment (F = 1.37, p = 0.2461). However, the dose of I-131 had significant effects on salivary gland function after I-131 treatment ( F = 9.72, p = 0.0002).
Conclusion: The present study did not show cytoprotective effects of amifostine for DTC patients treated with I-131.

• 出版日期2008-3
• 单位河北医科大学