Antifungal Activity of Plumericin and Isoplumericin

作者：Singh Dharmendra; Sharma Umakant; Kumar Parveen; Gupta Yogesh K; Dobhal M P; Singh Sarman^*

来源：Natural Product Communications, 2011, 6(11): 1567-1568.

DOI：10.1177/1934578x1100601101

• Candidiasis
• Cryptococcosis
• Plumeria bicolor
• Plumericin
• Isoplumericin

This study evaluated the in vitro anti fungal activity of the chloroform extract of Plumeria bicolor and its phytoconstituents plumericin and isoplumericin against Candid species and Cryptococcus neoformans by measuring the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). Plumericin's consistently high activity against Candid albicans, C. krusei, C. glabrata, C. tropicalis and Cryptococcus neoformans was more potent than isoplumericin and the standard antifungal drug nystatin suggesting its potential as a drug candidate for candidiasis and cryptococcosis.

• 出版日期2011-11
• 单位河北医科大学