Allylic fluorination via an unusual alkene Z/E isomerisation

作者：Laurenson James A B; Meiries Sebastien; Percy Jonathan M^*; Roig Ricard

来源：Tetrahedron Letters, 2009, 50(26): 3571-3573.

DOI：10.1016/j.tetlet.2009.03.068

The isomerisation of readily available (Z)-4-(para-methoxybenzyloxy)- 1 -chloro-2-butene was achieved under mild conditions to afford the much less accessible E-diastereoisomer. This was an effective Substrate in Sharpless asymmetric dihydroxylation (AD) reactions, delivering highly enantiomerically enriched fluorinated butene triol building blocks.

• 出版日期2009-7-1