A Meta Analysis on Prognostic Value of Patients with Non-Small Cell Lung Cancer

作者：Rui, Jiang^*; Li Yingping; Gu, Lijun; Wang, Zhiyan; Zuo, Jing; Zha, Lin

来源：Journal of Medical Imaging and Health Informatics, 2018, 8(9): 1875-1880.

DOI：10.1166/jmihi.2018.2564

• NE-kappa B
• Prognosis
• Lung Cancer
• NSCLC

Nuclear factor kappa B (NF-kappa B), a key nuclear transcription factor, is associated with prognosis in a variety of human cancers. However, the clinical value of NF-kappa B in non-small cell lung cancer (NSCLC) is still controversial. Therefore, the aim of this meta-analysis was to obtain an accurate evaluation of the relationship between NF-kappa B expression and survival prognosis of NSCLC patients based on published articles. PubMed, EMBASE and Web of Science databases were systematically searched for potential articles. A total of 1159 patients from 7 eligible studies comparing prognostic significance of NF-kappa B expression levels in NSCLC were included in our meta-analysis. I-2 statistic and P value were performed to evaluate heterogeneity using Review Manager version 5.3 The results of analysis were presented as hazard ratio (HR) or odds ratios with 95% confidence interval (95% CI). Subgroup analysis based on ethnicity of NSCLC patients was conducted to illustrate the potential discrepancy. Significant heterogeneity was considered at I-2 > 50% and P < 0.05, and random-effects model was used. The combined results indicated that higher NF-kappa B expression was associated with shorter overall survival of NSCLC patients (HR = 2.78, 95% CI = 1.51-5.12, P = 0.001). Moreover, NF-kappa B expression was closely associated with tumor stage (HR = 0.32, 95% CI = 0.18-0.57, P < 0.0001) and lymph node metastasis (HR = 0.56, 95% CI = 0.38-0.83, P = 0.004). We conclude that NF-kappa B expression may be a potential unfavorable prognostic marker for NSCLC patients.

• 出版日期2018-12
• 单位中国人民解放军总医院; 九江学院