NF-kappa B pathways in the development and progression of colorectal cancer

作者：Patel Meera^*; Horgan Paul G; Mcmillan Donald C; Edwards Joanne

来源：Translational Research, 2018, 197: 43-56.

DOI：10.1016/j.trs1.2018.02.002

Nuclear factor-kappa B (NF-kappa B) has been widely implicated in the development and progression of cancer. In colorectal cancer (CRC), NF-kappa B has a key role in cancer related processes such as cell proliferation, apoptosis, angiogenesis, and metastasis. The role of NF-kappa B in CRC is complex, owed to the cross talk with other signaling pathways. Although there is sufficient evidence gained from cell lines and animal models that NF-kappa B is involved in cancer-related processes, because of a lack of studies in human tissue, the clinical evidence of its importance is limited in patients with CRC. This review summarizes evidence relating to how NF-kappa B is involved in the development and progression of CRC and comments on future work to be carried out.

• 出版日期2018-7