Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia

作者：Holubiec Mariana I; Romero Juan I; Blanco Eduardo; Logica Tornatore Tamara; Suarez Juan; Rodriguez de Fonseca Fernando; Galeano Pablo^*; Capani Francisco

来源：Neuroscience Letters, 2017, 653: 269-275.

DOI：10.1016/j.neulet.2017.05.068

• Perinatal asphyxia
• DAGL alpha
• NAPE-PLD
• CBI
• PPAR alpha
• Dorsal striatum

Endocannabinoids (eCBs) and acylethanolamides (AEs) have lately received more attention due to their neuroprotective functions in neurological disorders. Here we analyze the alterations induced by perinatal asphyxia (PA) in the main metabolic enzymes and receptors of the eCBs/AEs in the dorsal striatum of rats. To induce PA, we used a model developed by Bjelke et al. (1991). Immunohistochemical techniques were carried out to determine the expression of neuronal and glial markers (NeuN and GFAP), eCBs/AEs synthesis and degradation enzymes (DAGL alpha, NAPE-PLD and FAAH) and their receptors (CB1 and PPAR alpha). We found a decrease in NAPE-PLD and PPAR expression. Since NAPE-PLD and PPAR alpha take part in the production and reception of biochemical actions of AEs, such as oleoylethanolamide, these results may suggest that PA plays a key role in the regulation of this system. These data agree with previous results obtained in the hippocampus and encourage us to develop further studies using AEs as potential neuroprotective compounds.

• 出版日期2017-7-13