Using NMR to determine the relative stereochemistry of 7,7-diaryl-8,8 '-dimethylbutan-1-ol lignans

作者：Davidson Samuel J; Rye Claire E; Barker David^*

来源：Phytochemistry Letters, 2015, 14: 138-142.

DOI：10.1016/j.phytol.2015.09.014

• Lignans
• Butanol lignans
• Seco lignans
• Stereochemical analysis

Due to their linear, freely rotatable, structure many natural 7,7-diaryl-8,8'-dimethylbutan-7'-ol lignans are reported without any stereochemical assignment. Analysis of synthetic 8,8'-dimethylbutanol lignans and analogues reveals significant differences between the NMR data of syn-and anti-isomers. This information was then used to determine the relative stereochemistry of the C-8 and C-8' methyl groups in previously undefined natural products.

• 出版日期2015-12