A near-infrared turn on fluorescent probe for cysteine based on organic nanoparticles

作者：Wang, Lingyun^*; Zhuo, Shaochun; Tang, Hao; Cao, Derong

来源：Sensors and Actuators B: Chemical , 2018, 277: 437-444.

DOI：10.1016/j.snb.2018.09.038

• Diketopyrrolopyrrole
• Fluorescent organic nanoparticles
• NIR emission
• Biothiol
• Aggregation-induced emission (AIE)

In this work, a NIR emissive luminogen (A1) containing tetraphenylethene, diketopyrrolopyrrole and nitroolefin moieties was synthesized. Through hydrophobic-hydrophilic interactions with Pluronic F127, A1-F127 based fluorescent organic nanoparticles (FONs) was prepared, which was intrinsically non-fluorescent due to presence of nitroolefin moiety. However, after being reacted with Cys, Michael addition of thiols to nitroolefin elicited a significant NIR fluorescent turn-on response at 654 nm. A1-F127 FONs can selectively discriminate Cys from GSH and Hcy with a detection limit of 5.31x10(-8) M. Its biocompatibility and cell imaging application were further investigated. The work could provide a general, simple and efficient strategy for the application of hydrophobic fluorescent molecules to sensing analytes in a totally aqueous system.

• 出版日期2018-12-20
• 单位华南理工大学