摘要
Assembly of pyridine-2-aldoxime drug with cucurbit [6] uril (CB[6]) has been investigated by 1H-NMR and 2D-ROESY NMR, UV-Vis spectroscopy, FT-IR spectroscopy, surface tension and conductivity measurements in aqueous saline environment. The distinct cationic receptor feature and the cavity dimension of the CB[6] emphasize that the macro-cyclic host molecule remain as complex with the nerve stimulus drug molecule. The results obtained from surface tension and specific conductivity measurements suggest 1:1 inclusion complex formation between drug and CB[6]. The stability constant evaluated by UV-Vis spectroscopic approach is 2.21 x 10(5) M-1 at 298.15 K, which indicates that the complex is sufficiently stable at physiological temperature.
- 出版日期2018-2