A Convenient Preparation of Bis(4-methoxyphenyl)methanethiol and Its Application in the Synthesis of Biotin Thioacid

作者：Chou Tzyy Chao; Hsu Yu Ling; Lo Lee Chiang^*

来源：Journal of the Chinese Chemical Society, 2014, 61(6): 707-710.

DOI：10.1002/jccs.201300664

• Thiol
• Thioester
• Thioacid
• Biotin
• Bis(4-methoxyphenyl)methyl

We have established a facile protocol for the preparation of bis(4-methoxyphenyl) methanethiol (4). Thiol 4 was used to prepare biotin thioester 7 which was later subjected to acidolysis to afford biotin thioacid (1b) in high yield. Compound 1b represents a new biotinylating reagent worth exploring and its spectral data was reported for the first time.

• 出版日期2014-6