Amyloid imaging using fluorine-19 magnetic resonance imaging (F-19-MRI)

作者：Tooyama Ikuo; Yanagisawa Daijiro; Taguchi Hiroyasu; Kato Tomoko; Hirao Koichi; Shirai Nobuaki; Sogabe Takayuki; Ibrahim Nor Faeizah; Inubushi Toshiro; Morikawa Shigehiro

来源：Ageing Research Reviews, 2016, 30: 85-94.

DOI：10.1016/j.arr.2015.12.008

• Amyloid imaging
• Alzheimer's disease
• Senile plaque
• Curcumin
• Styrylbenzoxazole
• F-19-MRI

The formation of senile plaques followed by the deposition of amyloid-beta is the earliest pathologicalchange in Alzheimer's disease. Thus, the detection of senile plaques remains the most important early diagnostic indicator of Alzheimer's disease. Amyloid imaging is a noninvasive technique for visualizing senile plaques in the brains of Alzheimer's patients using positron emission tomography (PET) or magnetic resonance imaging (MRI). Because fluorine-19 (F-19) displays an intense nuclear magnetic resonance signal and is almost non-existent in the body, targets are detected with a higher signal-to-noise ratio using appropriate fluorinated contrast agents. The recent introduction of high-field MRI allows us to detect amyloid depositions in the brain of living mouse using F-19-MRI. So far, at least three probes have been reported to detect amyloid deposition in the brain of transgenic mouse models of Alzheimer's disease; (E,E)-1-fluoro-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (FSB), 1,7-bis(4'-hydroxy-3'-trifluoromethoxyphenyl)-4-methoxycarbonylethyl-1,6-heptadiene3,5-dione (FMeCl, Shiga-Y5) and 6-(3',6',9',15',18',21'-heptaoxa-23',23',23'-trifluorotricosanyloxy)-2-(4'dimethylaminostyryl)benzoxazole (XP7, Shiga-X22). This review presents the recent advances in amyloid imaging using F-19-MRI, including our own studies.

• 出版日期2016-9