Kinetics of Cardiac Output at the Onset of Exercise in Precapillary Pulmonary Hypertension

作者：Lador Frederic; Bringard Aurelien; Bengueddache Samir; Ferretti Guido; Bendjelid Karim; Soccal Paola M; Noble Stephane; Beghetti Maurice; Chemla Denis; Herve Philippe; Sitbon Olivier

来源：Biomed Research International, 2016, 2016: 6050193.

DOI：10.1155/2016/6050193

Purpose. Cardiac output (CO) is a cornerstone parameter in precapillary pulmonary hypertension (PH). The Modelflow (MF) method offers a reliable noninvasive determination of its beat-by-beat changes. So MF allows exploration of CO adjustment with the best temporal resolution. Methods. Fifteen subjects (5 PHpatients, 10 healthy controls) performed a submaximal supine exercise on a cycle ergometer after 5 min of rest. COwas continuously determined byMF(COMF). Kinetics of heart rate (HR), stroke volume (SV), and CO were determined with 3monoexponential models. Results. In PH patients, we observed a sudden and transitory drop of SV upon exercise onset. This implied a transitory drop of CO whose adjustment to a new steady state depended on HR increase. The kinetics of HR and CO for PH patients was slower than that of controls for all models and for SV in model 1. SV kinetics was faster for PH patients in models 2 and 3. Conclusion. This is the first description of beat-by-beat cardiovascular adjustments upon exercise onset in PH. The kinetics of HR and CO appeared slower than those of healthy controls and there was a transitory drop of CO upon exercise onset in PH due to a sudden drop of SV.

• 出版日期2016