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摘要
A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX-Ru) was applied successfully to the asymmetric hydrogenation of beta-secondary amino ketones, directly affording the corresponding chiral gamma-secondary amino alcohols in up to 99% yield and with 99% ee. Reaction with beta-(benzylamino)-1-phenylpropan-1-one could be performed on a gram-scale with a relatively low catalyst loading (up to 2000 S/C). The resulting hydrogenated product could be used for the synthesis of synthetically useful compounds.
- 出版日期2015-10-12
- 单位上海交通大学
