科研之友
微信
新浪微博
Facebook
分享链接
摘要
gamma-Secretase is an intramembrane-cleaving protease that generates various forms of amyloid-beta peptides (A beta) that accumulate in the brains of Alzheimer's disease (AD) patients. The intracellular trafficking and subcellular localization of gamma-secretase are linked to both qualitative and quantitative changes in A beta production. However, the precise intracellular localization of gamma-secretase as well as its detailed regulatory mechanisms have remained elusive. Recent genetic studies on AD provide ample evidence that alteration of the subcellular localization of gamma-secretase contributes to the pathogenesis of AD. Here we review our current understanding of the intracellular membrane trafficking of gamma-secretase, the association between its localization and proteolytic activity, and the possibility of gamma-secretase as a therapeutic target against AD.
- 出版日期2016-9
