Lack of evidence for a major gene in the Mendelian transmission of BMI in Chinese

作者：Liu, PY; Li, YM; Li, MX; Malkin, I; Qin, YJ; Chen, XD; Liu, YJ; Deng, HW^*

来源：Obesity Research, 2004, 12(12): 1967-1973.

DOI：10.1038/oby.2004.247

• BMI
• Chinese population
• familial correlation
• segregation analysis
• major genes

Objectives: To determine the heritability of BMI and to examine the mode of inheritance of BMI variation in Chinese.
Research Methods and Procedures: Familial correlation and complex segregation analyses for BMI were undertaken in a Chinese sample composed of 392 nuclear families, with 1190 total individuals.
Results: A moderate heritability was found for BMI (h(2) = 0.419-0.492). The obtained results do not support a major gene for BMI in our samples. BMI may be inherited in a complex and non-Mendelian manner in Chinese.
Discussion: The findings of this study suggest that identification of specific genes for BMI in Chinese, at least within the same data set, is a serious challenge because of the lack of evidence of a major gene for BMI in our Chinese sample.

• 出版日期2004-12
• 单位湖南师范大学; 怀化学院