Mechanisms of weight maintenance under high- and low-protein, low-glycaemic index diets

作者：Rubio Aliaga Isabel^*; Marvin Guy Laure F; Wang Ping; Wagniere Sandrine; Mansourian Robert; Fuerholz Andreas; Saris Wim H M; Astrup Arne; Mariman Edwin C M; Kussmann Martin

来源：Molecular Nutrition & Food Research, 2011, 55(11): 1603-1612.

DOI：10.1002/mnfr.201100081

• Cardiovascular disease
• Dietary intervention
• Obesity
• Proteomics
• Weight management

Scope: Weight maintenance after intended weight loss is a challenge in an obesogenic environment. In a large multicentre dietary intervention study (DiOGenes), it has recently been demonstrated that a high-protein/low-glycaemic index (HP/LGI) diet was slightly more efficient in maintaining weight loss than low-protein/LGI or high-GI (LP/LGI or HGI) diets. Here, we use a proteomic approach to assess the molecular mechanisms behind this positive effect.
Methods and results: A subset of the most successful (weight loser, n = 12) and unsuccessful (weight re-gainer, n = 12) individuals consuming the LGI diets with either high- or low-protein content (HP or LP/LGI), following an initial calorie deficit run-in weight loss phase, were analyzed at the plasma protein level. Proteomic analysis revealed 18 proteins regulated after 6 months of the dietary weight maintenance phase. Furthermore, 12 proteins were significantly regulated as a function of success rate under an HP diet, arising as candidate biomarkers of mechanisms of successful weight maintenance under an HP/LGI diet. Pregnancy-zone protein (PZP) and protein S (PROS1) were revealed as novel biomarkers of weight maintenance showing opposite effects.
Conclusion: Semantic network analysis of the 12 regulated proteins revealed that under an HP/LGI an anti-atherogenic effect and alterations of fat metabolism were associated with the success of maintaining the initial weight loss.

• 出版日期2011-11