Antiadenohypophysis Autoantibodies in Patients with Nongluten-related Gastroenteropathies

作者：Aguado Rocio; Fernandez Silvia; Estevez Orlando A; Santamaria Manuel^*; Ortega Consuelo

来源：Journal of Clinical Laboratory Analysis, 2014, 28(1): 59-62.

DOI：10.1002/jcla.21644

• antipituitary antibodies
• gastroenterophaties
• celiac disease
• growth impairment
• pituitary

AimTo investigate the presence of antipituitary antibodies (APA) in the serum of patients undergoing gastroenteropathies (GEP) other than celiac disease (CD).
MethodsAPA were analyzed in GEP patients (n= 103), CD patients (n= 94), idiopathic growth hormone (GH) deficiency patients (n= 21), and 98 age- and sex-matched controls. Indirect immunofluorescence was performed in cryostat sections of baboon pituitary gland.
ResultsAPA were detected in 30% of GEP patients, 38% of them showed failure to thrive. No significant differences were found when we compared thrive impairment in negative and positive APA GEP patients. Indeed, normal values of insulin-like growth factor 1 were found in 93% of positive APA GEP patients. APA were detected in 52% of the CD patients. Ninety-one percent of them, in contrast to GEP group, showed significant growth impairment (P < 0.05) when compared to APA negative CD individuals. GH-deficient non-CD patients did not show APA.
ConclusionsWe have shown the presence of APA in patients with nongluten-related enteropathies. The presence of antipituitary autoantibodies in GEP patients does not seem to be associated with failure to thrive as it occurs in CD.

• 出版日期2014-1