Adipose stress-sensing kinases: linking obesity to malfunction

作者：Rudich Assaf; Kanety Hannah; Bashan Nava^*

来源：Trends in Endocrinology and Metabolism, 2007, 18(8): 291-299.

DOI：10.1016/j.tem.2007.08.006

Obesity has been proposed to inflict a variety of stresses on adipose tissue, including inflammatory, metabolic, oxidative and endoplasmic reticulum stress. Through the activation of 'stress-sensing pathways', metabolic and endocrine alterations are produced, which probably contribute to the co-morbidities associated with obesity. Here, we review the evidence supporting the development of various obesity-related stresses and the activation of several stress-sensing pathways, specifically in adipocytes and/or adipose tissue, which manifest metabolic and endocrine dysfunction frequently in obesity. As the central role of adipose tissue in regulating wholebody metabolism is elucidated, understanding adipose tissue stress-sensing pathways might provide potential new therapeutic targets to attenuate obesity-related morbidity.

• 出版日期2007-10