Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease

作者：Baldry Mara^*; Nakamura Yuumi; Nakagawa Seitaro; Frees Dorte; Matsue Hiroyuki; Nunez Gabriel; Ingmer Hanne

来源：Journal of Infectious Diseases, 2018, 218(6): 1009-1013.

DOI：10.1093/infdis/jiy259

• Staphylococcus aureus
• agr quorum sensing inhibition
• atopic dermatitis
• delta-toxin
• antivirulence therapy

Atopic dermatitis (AD) is a chronic inflammatory skin disease where more than 90% of patients affected are colonized with Staphylococcus aureus. In AD, S. aureus delta-toxin is a major virulence factor causing cutaneous inflammation via mast cell degranulation. d-toxin is controlled by the S. aureus agr quorum sensing system, and thus we addressed whether interference with agr signaling would limit skin inflammation. Indeed, treatment of S. aureus with the agr-inhibitor solonamide B (SolB) abolished d-toxin production and reduced skin inflammation in a mouse model of inflammatory skin disease, demonstrating the potential of antivirulence therapy in treating S. aureus-induced skin disorders.

• 出版日期2018-9-15