Anatomical Characteristics of the Cerebral Surface in Bulimia Nervosa

作者：Marsh Rachel^*; Stefan Mihaela; Bansal Ravi; Hao Xuejun; Walsh B Timothy; Peterson Bradley S

来源：Biological Psychiatry, 2015, 77(7): 616-623.

DOI：10.1016/j.biopsych.2013.07.017

• Bulimia nervosa
• Eating disorders
• Frontal cortex
• Frontostriatal
• MRI
• Surface morphology

BACKGROUND: The aim of this study was to examine morphometric features of the cerebral surface in adolescent and adult female subjects with bulimia nervosa (BN).
METHODS: Anatomical magnetic resonance images were acquired from 34 adolescent and adult female subjects with BN and 34 healthy age-matched control subjects. We compared the groups in the morphological characteristics of their cerebral surfaces while controlling for age and illness duration.
RESULTS: Significant reductions of local volumes on the brain surface were detected in frontal and temporoparietal areas in the BN compared with control participants. Reductions in inferior frontal regions correlated inversely with symptom severity, age, and Stroop interference scores in the BN group.
CONCLUSIONS: These findings suggest that local volumes of inferior frontal regions are smaller in individuals with BN compared with healthy individuals. These reductions along the cerebral surface might contribute to functional deficits in self-regulation and to the persistence of these deficits over development in BN.

• 出版日期2015-4-1