A highly selective fluorescent 'turn-on' chemosensor for Hg2+ based on a phthalazin-hydrazone derivative and its application in human cervical cancer cell imaging

作者：Mahajan Dipesh; Khairnar Nilesh; Bondhopadhyay Banashree; Sahoo Suban K; Basu Anupam; Singh Jasminder; Singh Narinder^*; Bendre Ratnamala; Kuwar Anil

来源：New Journal of Chemistry, 2015, 39(4): 3071-3076.

DOI：10.1039/c4nj02149e

A new phthalazin-hydrazone based fluorescent chemosensor (E)-5-(diethylamino)-2-((2-(phthalazin-1-yl)-hydrazono) methyl) phenol (1) was reported. Sensor 1 showed a high selectivity and sensitivity towards Hg2+ by giving significant fluorescence enhancement at 550 nm over other tested cations in DMSO/H2O (80 : 20, v/v) medium. The association constant was 1.0 x 104 M-1 between sensor 1 and Hg2+. Sensor 1 showed a nanomolar detection limit of 26.1 nM Hg2+. Finally, the fluorescence imaging experiments for the detection of intracellular Hg2+ in human cervical cancer HeLa cells showed its practical utility in biological samples.

• 出版日期2015