Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

作者：McDonald Hyman Cameron; Turka Laurence A; Blazar Bruce R^*

来源：Science Translational Medicine, 2015, 7(280): 280rv2.

DOI：10.1126/scitranslmed.aaa6853

Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.

• 出版日期2015-3-25