Novel technologies to detect atelectotrauma in the injured lung

作者：Shi Chang^*; Boehme Stefan; Hartmann Erik K; Markstaller Klaus

来源：Experimental Lung Research, 2011, 37(1): 18-25.

DOI：10.3109/01902148.2010.501402

• acute lung injury
• arterial oxygen saturation
• cyclical recruitment and derecruitment
• dynamic computed tomography
• electrical impedance tomography
• PaO2 oscillation

Cyclical recruitment and derecruitment of lung parenchyma (R/D) remains a serious problem in ALI/ARDS patients, defined as atelectotrauma. Detection of cyclical R/D to titrate the optimal respiratory settings is of high clinical importance. Image-based technologies that are capable of detecting changes of lung ventilation within a respiratory cycle include dynamic computed tomography (dCT), synchrotron radiation computed tomography (SRCT), and electrical impedance tomography (EIT). Time-dependent intra-arterial oxygen tension monitoring represents an alternative approach to detect cyclical R/D, as cyclical R/D can result in oscillations of PaO2 within a respiratory cycle. Continuous, ultrafast, on-line in vivo measurement of PaO2 can be provided by an indwelling PaO2 probe. In addition, monitoring of fast changes in SaO(2) by pulse oximetry technology at the bedside could also be used to detect those fast changes in oxygenation.

• 出版日期2011-2