Unhealthy dietary patterns associated with inflammation and endothelial dysfunction in type 1 diabetes: The EURODIAB study

作者：van Bussel B C T^*; Soedamah Muthu S S; Henry R M A; Schalkwijk C G; Ferreira I; Chaturvedi N; Toeller M; Fuller J H; Stehouwer C D A

来源：Nutrition Metabolism and Cardiovascular Diseases, 2013, 23(8): 758-764.

DOI：10.1016/j.numecd.2012.04.005

• Diet
• Type 1 diabetes
• Endothelial dysfunction
• Inflammation
• Epidemiology

Background and aims: A healthy diet has been inversely associated with endothelial dysED) and low-grade inflammation (LGI). We investigated the association between nutrient consumption and biomarkers of ED and LGI in type 1 diabetes. %26lt;br%26gt;Methods and results: We investigated 491 individuals. Nutrient consumption and lifestyle risk factors were measured in 1989 and 1997. Biomarkers of ED (von Willebrand factor, soluble vascular cell adhesion molecule-1 and soluble endothelial selectin) and LGI (C-reactive protein, interleukin 6 and tumour necrosis factor alpha) were measured in 1997 and averaged into Z-scores. The nutrient residual method was used to adjust individual nutrient intake for energy intake. Data were analysed with generalised estimation equations. We report increments/decrements in nutrient consumption, averaged over time, per +1 standard deviation (SD) of 1997 ED or LGI Z-scores, after adjustment for sex, age, duration of diabetes, investigation centre, body mass index, energy intake, smoking behaviour, alcohol consumption, and each of the other nutrients. One SD elevation in ED Z-score was associated with a diet lower in fibre [beta(95%CI); -0.09(-0.18; -0.004)], polyunsaturated fat [-0.18(-0.31; -0.05)] and vegetable protein [-0.10(-0.20; -0.001)]. For the LGI Z-score results showed associations with fibre [-0.09(-0.17; -0.01)], polyunsaturated fat [-0.14(-0.24; -0.03)] and cholesterol [0.10(0.01; 0.18)]. %26lt;br%26gt;Conclusion: In type 1 diabetes, consumption of less fibre, polyunsaturated fat and vegetable protein, and more cholesterol over the study period was associated with more ED and LGI. Following dietary guidelines in type 1 diabetes may reduce cardiovascular disease risk by favourably affecting ED and LGI.

• 出版日期2013-8