Association of UCP3, APN, and TNF-α Gene Polymorphisms with Type 2 Diabetes in a Population of Northern Chinese Han Patients

作者：Wang Ling-ling; Du Zhen-wu; Liu Jia-nan; Wu Mei; Song Yang; Jiang Ri-hua^*; Zhang Gui-zhen

来源：Chemical Research in Chinese Universities, 2012, 28(2): 255-258.

• Uncoupling protein 3(UCP3)
• Adiponectin(APN)
• Tumor necrosis factor(TNF)-alpha
• Gene polymorphism
• Type 2 diabete(T2DM) risk

We observed the polymorphism distribution and coaction of uncoupling protein 3(UCP3)-55C/T, adiponectin(APN)+45T/G and tumor necrosis factor(TNF)-alpha-308G/A on the onset and development of T2DM in a Northern Chinese Han population of 213[100 type 2 diabete(T2DM) patients and 113 health control subjects] by polymerase chain reaction-restriction fragment length polymorphisum(PCR-RFLP) method. Results demonstrate the polymorphism of UCP3-55C/T, APN+45T/G, and TNF-alpha-308G/A related to T2DM onset and developement. And the individuals carrying UCP3-55T, APN+45G and TNF-alpha-308A allele had higher T2DM risk. Those results are the first report to evaluate the association of the coaction of UCP3, APN, TNF-alpha genes polymorphism on T2DM risk and the susceptibility of T2DM in the Northern Chinese Han population.

• 出版日期2012-3
• 单位吉林大学; 北华大学