Alternative parameterizations of relatedness in whole genome association analysis of pre-weaning traits of Nelore-Angus calves

作者：Riley David G^*; Gill Clare A; Herring Andy D; Riggs Penny K; Sawyer Jason E; Sanders James O

来源：Genetics and Molecular Biology, 2014, 37(3): 518-525.

DOI：10.1590/s1415-47572014000400007

• birth weight
• gestation length
• weaning weight
• Nelore
• whole genome association

Gestation length, birth weight, and weaning weight of F 2 Nelore-Angus calves (n = 737) with designed extensive full-sibling and half-sibling relatedness were evaluated for association with 34,957 SNP markers. In analyses of birth weight, random relatedness was modeled three ways: 1) none, 2) random animal, pedigree-based relationship matrix, or 3) random animal, genomic relationship matrix. Detected birth weight-SNP associations were 1,200, 735, and 31 for those parameterizations respectively; each additional model refinement removed associations that apparently were a result of the built-in stratification by relatedness. Subsequent analyses of gestation length and weaning weight modeled genomic relatedness; there were 40 and 26 trait-marker associations detected for those traits, respectively. Birth weight associations were on BTA14 except for a single marker on BTA5. Gestation length associations included 37 SNP on BTA21, 2 on BTA27 and one on BTA3. Weaning weight associations were on BTA14 except for a single marker on BTA10. Twenty-one SNP markers on BTA14 were detected in both birth and weaning weight analyses.

• 出版日期2014