Adverse drug reactions in an emergency medical dispatching centre

作者：Dehours E^*; Bounes V; Bagheri H; Valle B; Ducasse J L; Montastruc J L

来源：European Journal of Clinical Pharmacology, 2014, 70(7): 881-887.

DOI：10.1007/s00228-014-1685-y

• Adverse drug reaction
• Serious adverse drug reaction
• Emergency call
• Emergency medical dispatching centre

The purpose of this study is to assess the incidence of adverse drug reactions (ADR) leading to call an emergency medical dispatching centre. %26lt;br%26gt;A prospective, observational, monocentric clinical study performed over a 2-year period (2011-2012) in a French prehospital emergency dispatching centre, the Service d%26apos;Aide M,dicale Urgente (SAMU) covering 1,156,000 inhabitants. All adult patients (age a parts per thousand yenaEuro parts per thousand 18) who called for any cause were included. We created an electronic trigger %26apos;iatrogenic event%26apos; implemented by the dispatching physician for each suspected case of ADR, then we completed the analyses of all the cases with a chief complain represented in more than 1 % of the triggered cases. The primary outcome variable was the occurrence of any possible ADR. We then used the French method of causal relationship assessment. %26lt;br%26gt;The SAMU dispatched 339,915 calls during the study. In total, 1,467 ADRs were identified, representing 0.95 % (CI 95 % 0.90-1.00 %) of cases. ADRs were as serious (SADR) in 51.06 % (CI 95 % 48.45-53.67 %) of cases. The major ADR observed was haemorrhage, (42.81 % (CI 95 % 40.62-45.00 %), n = 628) followed by allergy, hypoglycaemia, vomiting, dizziness and drowsiness. The class of drugs most frequently involved was antithrombotic (43.69 % (CI 95 % 41.45-45.93 %), n = 641), followed by insulin (17.98 % (CI 95 %:17.06-18.90 %), n = 264). %26lt;br%26gt;Emergency calls concerning ADRs were estimated as 9/1,000, and one out of two is serious.

• 出版日期2014-7