Protective effects, of atypical antipsychotic drugs against MPP+-induced oxidative stress in PC12 cells

作者：Park Sung Woo; Lee Chan Hong; Lee Jung Goo; Kim Luck Woo; Shin Bae Sub; Lee Bong Ju; Kim Young Hoon^*

来源：Neuroscience Research, 2011, 69(4): 283-290.

DOI：10.1016/j.neures.2011.01.004

• Atypical antipsychotic drug
• Oxidative stress
• MPP+
• SOD
• ROS
• Bax

Recent studies have suggested that some atypical antipsychotic drugs may have protective properties against oxidative stress. To confirm these findings, we investigated the protective effects of atypical antipsychotic drugs such as olanzapine, aripiprazole, and ziprasidone on oxidative stress induced by the N-methyl-4-phenylpyridinium (MPP+) ion in PC12 cells. Haloperidol, a typical antipsychotic drug, was used for comparison. We determined the antioxidant effects of atypical antipsychotic drugs using a number of measures, including cell viability, the formation of reactive oxygen species (ROS), superoxide dismutase (SOD) activity and Bax levels. MPP+ treatment induced significant loss of cell viability, the formation of ROS, reduction of SOD activity, and up-regulation of Bait expression. However, olanzapine, aripiprazole and ziprasidone reversed these effects caused by MPP+ treatment, but ziprasidone did not influence cell viability. In contrast, haloperidol did not affect all these effects. Moreover, haloperidol strongly increased the expression of Bax under MPP+-free condition;. Olanzapine, aripiprazole, and ziprasidone, but not haloperidol, may exert antioxidant effects through m adulating ROS levels, SOD activity, and Bax expression to provide protective effects against MPP+-induced oxidative stress in PC12 cells. These results suggest that some atypical antipsychotic drugs have a useful therapeutic effect by reducing oxidative stress in schizophrenic patients.

• 出版日期2011-4