Urethral dysfunction due to alloxan-induced diabetes. Urodynamic evaluation and action of sildenafil citrate(1)

作者：Gomes de Souza Pegorare Ana Beatriz; Goncalves Marco Antonio; de Oliveira Alessandra Martiniano; Rodrigues Junior Antonio Antunes; Tucci Silvio Jr; Suaid Haylton Jorge

来源：Acta Cirurgica Brasileira, 2014, 29(4): 274-279.

DOI：10.1590/S0102-86502014000400009

• Diabetes Mellitus
• Urethra
• Urinary Bladder
• Rats

PURPOSE:To evaluate the effect of diabetes mellitus and of sildenafil citrate on female urethral function.
METHODS: Twenty nine female rats were divided into four groups: G1 -(n= 9), normal rats; G2 -(n= 6), normal rats treated with sildenafil citrate; G3-(n= 9) rats with alloxan-induced diabetes; G4 -(n= 5) rats with alloxan-induced diabetes treated with sildenafil citrate. Under anesthesia, urodynamic evaluation was performed by cystometry and urethral pressure simultaneously.
RESULTS: A significant increase in urethral pressure was observed during micturition.
CONCLUSION: Sildenafil citrate can partially reduced urethral pressure in diabetic female rats.

• 出版日期2014-4