AN EFFICIENT ONE-POT SYNTHESIS OF AZULENO [2,1-b]PYRIDAZINES

作者:Wang, Dao-Lin*; Ma, Jian; Shi, Xiao-Ce; Wu, Jian-Ying
来源:Heterocycles, 2016, 92(1): 133-140.
DOI:10.3987/COM-15-13364

摘要

A simple and efficient procedure was developed for the synthesis of 1-aryl-3-cyano-4-oxo- 10-ethoxycarb onylazuleno [2,1-b]pyridazines (3) in good yields by condensation of ethyl 1-cyanoacetyl-2-methoxyazulene-3-carboxylate (1) with aryldiazonium salt (2) in pyridine via a domino reaction. This reaction provides a new procedure for synthesis of heterocyle-fused azulenes.