A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm

作者：Gai, Yongkang; Hu, Zhongping; Rong, Zhao; Ma, Xiang^*; Xiang, Guangya

来源：Molecules, 2015, 20(10): 19393-19405.

DOI：10.3390/molecules201019393

• 1
• 4
• 7-triazonane
• hydroxypyridinonate
• metal chelator

The preparation of triazamacrocyclic hydroxypyridinonate (HOPO-TACN) derivatives as potential chelators for metals in biomedical applications was reported. The synthesis is based on a convergent synthetic approach, in which the key intermediate di-tert-butyl-2,2-(1,4,7-triazonane-1,4-diyl) diacetate was coupled with a hydroxypyridinonate pendant arm. The method is suitable for rapid syntheses of metal chelator HOPO-TACNs of biomedical interest.

• 出版日期2015-10
• 单位华中科技大学