A new isoquinoline alkaloid with anti-microbial properties from Berberis jaeschkeana Schneid. var. jaeschkeana

作者：Alamzeb Muhammad^*; Khan M Rafiullah; Mamoon ur Rashid; Ali Saqib; Khan Ashfaq Ahmad

来源：Natural Product Research, 2015, 29(8): 692-697.

DOI：10.1080/14786419.2014.981187

• Berberis jaeschkeana
• anti-microbial
• berberidione

One new isoquinoline alkaloid named berberidione (1) along with four new source alkaloids berberine (2), palmatine (3), jatrorrhizine (4) and chondrofoline (5) and three new source non-alkaloids syringic acid (6), beta-sitosterol (7) and stigmasterol (8) was isolated and characterised from different fractions of Berberis jaeschkeana Schneid var. jaeschkeana. All the structures were determined from 1D and 2D spectroscopic data. Crude extract, sub-fractions and isolated compounds showed excellent anti-microbial properties. The toxicity level for the alkaloids was found to be very low on THP-1 cells.

• 出版日期2015-4-18