Association of single nucleotide polymorphisms of interleukin-1 family with atopic dermatitis

作者：Behniafard N; Gharagozlou M; Sotoudeh S; Farhadi E; Khaledi M; Moghaddam Z G; Mahmoudi M; Fathi S M; Darabi B; Aghamohammadi A; Amirzargar A A; Rezaei N^*

来源：Allergologia et Immunopathologia, 2014, 42(3): 212-215.

DOI：10.1016/j.aller.2012.09.005

• Atopic dermatitis
• Cytokine
• Interleukin-1
• Single nucleotide
• polymorphisms

Background: Interleukin-1 (IL-1) seems to have an important role in early reactions towards microbes, while its genetic variability could affect this role in atopic patients who have a distressed immunity towards dermatological infections.
Methods: Eighty-nine patients with atopic dermatitis (AD), who were referred to a main referral paediatric hospital, were enrolled in this study. Single nucleotide polymorphisms (SNP) of the following IL-1 cluster genes were assessed in this group of patients: IL-1 alpha -889, IL-1 beta -511, IL-1 beta +3962, IL-1R Pst-I 1970, and IL-1RA Mspa-I 11100. The results were compared with a group of 140 healthy subjects from the same region.
Results: Fourteen percent of the controls had TT homozygous genotype in IL-1R at position Pst-I 1970, while only 2% of the patients with AD had this genotype (p=0.005, OR: 0.14, 95%CI: 0.02-0.64). The CC homozygous genotype was the most common genotype in IL-1 alpha position -889 and IL-1 beta at position +3962 in both groups of patients with AD and the controls, while the TC heterozygous genotype was the most common genotype in IL-1 beta at position -511 and IL-1R at position Pst-I 1970, with no significant difference between the two groups.
Conclusions: This study showed a significant negative association in the IL-1R Mspa-I 11100 TT homozygous genotype in the patients with AD.

• 出版日期2014-6