Anticipated Intraoperative Electron Beam Boost, External Beam Radiation Therapy, and Limb-Sparing Surgical Resection for Patients with Pediatric Soft-Tissue Sarcomas of the Extremity: A Multicentric Pooled Analysis of Long-Term Outcomes

作者：Sole Claudio V^*; Calvo Felipe A; Polo Alfredo; Cambeiro Mauricio; Alvarez Ana; Gonzalez Carmen; Gonzalez Jose; San Julian Mikel; Martinez Monge Rafael

来源：International Journal of Radiation Oncology, Biology, Physics, 2014, 90(1): 172-180.

DOI：10.1016/j.ijrobp.2014.05.026

Purpose: To perform a joint analysis of data from 3 contributing centers within the intraoperative electron-beam radiation therapy (IOERT)-Spanish program, to determine the potential of IOERT as an anticipated boost before external beam radiation therapy in the multidisciplinary treatment of pediatric extremity soft-tissue sarcomas. %26lt;br%26gt;Methods and Materials: From June 1993 to May 2013, 62 patients (aged %26lt;21 years) with a histologic diagnosis of primary extremity soft-tissue sarcoma with absence of distant metastases, undergoing limb-sparing grossly resected surgery, external beam radiation therapy (median dose 40 Gy) and IOERT (median dose 10 Gy) were considered eligible for this analysis. %26lt;br%26gt;Results: After a median follow-up of 66 months (range, 4-235 months), 10-year local control, disease-free survival, and overall survival was 85%, 76%, and 81%, respectively. In multivariate analysis after adjustment for other covariates, tumor size %26gt;5 cm (P = .04) and R1 margin status (P = .04) remained significantly associated with local relapse. In regard to overall survival only margin status (P = .04) retained association on multivariate analysis. Ten patients (16%) reported severe chronic toxicity events (all grade 3). %26lt;br%26gt;Conclusions: An anticipated IOERT boost allowed for external beam radiation therapy dose reduction, with high local control and acceptably low toxicity rates. The combined radiosurgical approach needs to be tested in a prospective trial to confirm these results.

• 出版日期2014-9-1