Duplications of an iron-sulphur tripeptide leads to the formation of a protoferredoxin

作者：Scintilla Simone; Bonfio Claudia; Belmonte Luca; Forlin Michele; Rossetto Daniele; Li Jingwei; Cowan James A; Galliani Angela; Arnesano Fabio; Assfalg Michael; Mansy Sheref S

来源：Chemical Communications, 2016, 52(92): 13456-13459.

DOI：10.1039/c6cc07912a

Based on UV-Vis, NMR, and EPR spectroscopies and DFT and molecular dynamics calculations, a model prebiotic [2Fe-2S] tripeptide was shown to accept and donate electrons. Duplications of the tripeptide sequence led to a protoferredoxin with increased stability. Duplications of primitive peptides may have contributed to the formation of contemporary ferredoxins.

• 出版日期2016