A divergent approach to the total synthesis of the marine pyridoacridine alkaloid eilatin and its synthetic isomer isoeilatin

作者：Plodek Alois; Bracher Franz^*

来源：Tetrahedron Letters, 2015, 56(11): 1445-1447.

DOI：10.1016/j.tetlet.2015.01.176

• Total synthesis
• Alkaloids
• Pyridoacridines
• Eilatin
• Isoeilatin

Herein we report the total synthesis of the heptacyclic pyridoacridine alkaloid eilatin (1) and its synthetic isomer isoeilatin (2). Starting from readily available 9-methyl-3,4-dihydroacridin-1(2H)-one (5) and 2-aminoacetophenone, a divergent synthesis gave alkaloid 1 in seven, and isomer 2 in eight steps.

• 出版日期2015-3-11