Asymmetric synthesis of hydroxylated pyrrolidines, piperidines and related bioactive compounds: From N-acyliminium chemistry to N-alpha-carbanion chemistry

作者：Huang Pei Qiang^*

来源：Synlett, 2006, 2006(8): 1133-1149.

DOI：10.1055/s-2006-941565

• pyrrolidines
• 2-pyrrolidinones
• beta-hydroxy-gamma-amino acids
• N-acyliminium
• piperidines
• 2-piperidinones
• alpha-amidoalkylation
• sulfones
• sulfides
• samarium diiodide
• N-alpha-carbanion
• isoindolin-1-ones
• tetramic acids
• tetramates
• alkaloids
• synthons
• building blocks
• Umpolung

This account describes our recent studies on the development of chiral nonracemic cyclic imide-based synthetic methodology and the complementary N-alpha-carbanion synthon-based synthetic methodology for the asymmetric syntheses of naturally occurring or pharmaceutically interesting hydroxylated pyrrolidines, 2-pyrrolidinones, (beta-hydroxy-gamma-amino acids, and their higher homologous; as well as isoindolin-1-ones; tetramic acid and tetramate derivatives.

• 出版日期2006-5-15
• 单位厦门大学