Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women

作者：Melzer David^*; O**orne Nicholas J; Henley William E; Cipelli Riccardo; Young Anita; Money Cathryn; McCormack Paul; Luben Robert; Khaw Kay Tee; Wareham Nicholas J; Galloway Tamara S

来源：Circulation, 2012, 125(12): 1482-1490.

DOI：10.1161/CIRCULATIONAHA.111.069153

• bisphenol A
• blood lipids
• body mass index
• coronary artery disease
• endocrine disruption

Background-The endocrine-disrupting chemical bisphenol A (BPA) is widely used in food and beverage packaging. Higher urinary BPA concentrations were cross-sectionally associated with heart disease in National Health and Nutrition Examination Survey (NHANES) 2003-2004 and NHANES 2005-2006, independent of traditional risk factors. %26lt;br%26gt;Methods and Results-We included 758 incident coronary artery disease (CAD) cases and 861 controls followed for 10.8 years from the European Prospective Investigation of Cancer-Norfolk UK. Respondents aged 40 to 74 years and free of CAD, stroke, or diabetes mellitus provided baseline spot urine samples. Urinary BPA concentrations (median value, 1.3 ng/mL) were low. Per-SD (4.56 ng/mL) increases in urinary BPA concentration were associated with incident CAD in age-, sex-, and urinary creatinine-adjusted models (n = 1919; odds ratio = 1.13; 95% confidence interval, 1.02-1.24; P = 0.017). With CAD risk factor adjustment (including education, occupational social class, body mass index category, systolic blood pressure, lipid concentrations, and exercise), the estimate was similar but narrowly missed 2-sided significance (n = 1744; odds ratio = 1.11; 95% confidence interval, 1.00-1.23; P = 0.058). Sensitivity analyses with the fully adjusted model, excluding those with early CAD (%26lt;3-year follow-up), body mass index %26gt;30, or abnormal renal function or with additional adjustment for vitamin C, C-reactive protein, or alcohol consumption, all produced similar estimates, and all showed associations at P %26lt;= 0.05. %26lt;br%26gt;Conclusions-Associations between higher BPA exposure (reflected in higher urinary concentrations) and incident CAD during %26gt;10 years of follow-up showed trends similar to previously reported cross-sectional findings in the more highly exposed NHANES respondents. Further work is needed to accurately estimate the prospective exposure-response curve and to establish the underlying mechanisms. (Circulation. 2012;125:1482-1490.)

• 出版日期2012-3-27