An Adjuvanted, Tetravalent Dengue Virus Purified Inactivated Vaccine Candidate Induces Long-Lasting and Protective Antibody Responses Against Dengue Challenge in Rhesus Macaques

作者：Fernandez Stefan; Thomas Stephen J; De la Barrera Rafael; Im Erbsin Rawiwan; Jarman Richard G; Baras Benoit; Toussaint Jean Francois; Mossman Sally; Innis Bruce L; Schmidt Alexander; Malice Marie Pierre; Festraets Pascale; Warter Lucile; Putnak J Robert; Eckels Kenneth H^*

来源：The American Journal of Tropical Medicine and Hygiene, 2015, 92(4): 698-708.

DOI：10.4269/ajtmh.14-0268

The immunogenicity and protective efficacy of a candidate tetravalent dengue virus purified inactivated vaccine (TDENV PIV) formulated with alum or an Adjuvant System (AS01, AS03 tested at three different dose levels, or AS04) was evaluated in a 0,1-month vaccination schedule in rhesus macaques. One month after dose 2, all adjuvanted formulations elicited robust and persisting neutralizing antibody titers against all four dengue virus serotypes. Most of the formulations tested prevented viremia after challenge, with the dengue serotype 1 and 2 virus strains administered at 40 and 32 weeks post-dose 2, respectively. This study shows that inactivated dengue vaccines, when formulated with alum or an Adjuvant System, are candidates for further development.

• 出版日期2015-4