科研之友
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摘要
The linear correlation between C-11-methionine PET and tumor cell density is not well conserved at the tumor border in glioma. A novel imaging analysis method, voxelwise F-18-FDG-C-11-methionine PET decoupling analysis (decoupling score), was evaluated to determine whether it could be used to quantitatively assess glioma cell infiltration in MRI-nonenhancing T2 hyperintense lesions. Methods: Data collection was performed in a prospective fashion. Fifty-four MRI-nonenhancing T2 hyperintense specimens were stereotactically obtained from 23 glioma patients by intraoperative navigation guidance. The decoupling score and tumor-to-normal tissue (TIN) ratio of C-11-methionine PET were calculated at each location. Correlations between the tumor cell density at these lesions, decoupling score, and TIN ratio of C-11-methionine PET were then evaluated. Results: Both the decoupling score and the T/N ratio showed a linear correlation with tumor cell density at these specimens (R-2 = 0.52 and 0.53, respectively). Use of the decoupling score (cutoff = 3.0) allowed the detection of specimens with a tumor cell density of more than 1,000/mm(2), with a sensitivity and specificity of 93.5% and 87.5%, respectively, whereas conventional C-11-methionine PET (cutoff = 1.2 in T/N ratio) was able to detect with a sensitivity and specificity of 87.0% and 87.5%, respectively. Reconstructed images (decoupling map) using the decoupling score enabled the visualization of glioma lesions that were difficult to visualize by C-11-methionine PET alone. Conclusion: The decoupling score showed better performance in detecting glioma cell infiltration than C-11-methionine uptake alone, thus suggesting that F-18-FDG-C-11-methionine uptake decoupling analysis is a powerful imaging modality for assessing glionia invasion.
- 出版日期2012-11
