Contact allergens induce CD8(+) T cell-derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity

作者：Dolch Anja; Kunz Stefanie; Dorn Britta; Roers Axel; Martin Stefan F; Jakob Thilo^*

来源：Experimental Dermatology, 2017, 26(5): 449-451.

DOI：10.1111/exd.13237

• allergic contact dermatitis
• contact hypersensitivity
• immune regulation
• skin
• T cell

Interleukin 10 (IL-10) has been implied in the regulation of allergic contact dermatitis. Using transcriptional reporter mice we analyzed cellular sources of IL-10 during contact hypersensitivity (CHS) and identified IL-10 expressing CD8(+) T cells in the skin that are antigen-specific, display PD-1, an effector memory phenotype, and IL-10 expression comparable to that of CD4(+) T cells. However, in mice with a selective IL-10 deficiency in CD8(+) T cells CHS responses were comparable to that of controls, even in the absence of CD4(+) cells, suggesting that CD8(+) T cell-derived IL-10 does not contribute significantly to the resolution of CHS responses.

• 出版日期2017-5