科研之友
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摘要
An efficient and novel synthesis of benzimidazole-linked indoline hybrids via an unconventional Pictet-Spengler-type condensation of C-2 linked (o-aminobenzyl) benzimidazoles with aldehydes and ketones under microwave irradiation has been explored. The key condensation step consists of acid-catalyzed imine generation followed by intramolecular C-C bond formation through unique reactivity of the benzimidazole moiety. The scope of this method is further extended to synthesize tetracyclic pyrroloindole benzimidazole-carboxylates through 2-carboxaldehydes.
- 出版日期2018-2-1
