Deep Brain Stimulation of the Prelimbic Medial Prefrontal Cortex: Quantification of the Effect on Glucose Metabolism in the Rat Brain Using [(18) F]FDG MicroPET

作者：Parthoens Joke; Verhaeghe Jeroen; Stroobants Sigrid; Staelens Steven^*

来源：Molecular Imaging and Biology, 2014, 16(6): 838-845.

DOI：10.1007/s11307-014-0757-9

• Dorsolateral prefrontal cortex
• Medial prefrontal cortex
• Deep brain stimulation
• [F-18]FDG microPET
• Addiction
• Depression

Prefrontal cortex (PFC) deep brain stimulation (DBS) has been proposed as a therapy for addiction and depression. This study investigates changes in rat cerebral glucose metabolism induced by different DBS frequencies using mu PET. %26lt;br%26gt;One hour DBS of the prelimbic area (PL) of the medial PFC (mPFC) (60 Hz, 130 Hz or sham) in rats (n = 9) was followed by 2-deoxy-2-[(18) F] fluoro-d-glucose ([(18) F]FDG) mu PET. %26lt;br%26gt;Sixty Hz DBS elicited significant hypermetabolism in the ipsilateral PL ([(18) F]FDG uptake +5.2 +/- 2.3 %, p %26lt; 0.05). At 130 Hz, hypometabolism was induced in the ipsilateral PL (-2.5 +/- 2.6 %, non-significant). Statistical parametric mapping revealed hypo and hypermetabolism clusters for both 60 and 130 Hz versus sham and show a certain state of alertness (increased activity in sensory and motor-related regions) mainly for 60 Hz. %26lt;br%26gt;This study suggests the potential of 60 Hz PL mPFC DBS for the treatment of disorders associated with prefrontal hypofunction.

• 出版日期2014-12