Macular parameters of Stratus optical coherence tomography for assessing glaucoma in high myopia

作者：Hung, Kuo Chi; Wu, Pei Chang; Chang, Hsueh Wen; Lai, Ing Chou; Tsai, Jen Chia; Lin, Pei Wen; Teng, Mei Ching^*

来源：Clinical and Experimental Optometry, 2015, 98(1): 39-44.

DOI：10.1111/cxo.12227

• glaucoma
• high myopia
• macula
• optical coherence tomography

BackgroundThe aim was to assess the macular parameters of glaucoma in highly myopic subjects.
MethodsIn a retrospective study, we enrolled 72 highly myopic eyes (spherical equivalent up to -6.00D), of which 31 had early to moderate glaucoma and 41 formed a control group. The diagnosis of early to moderate glaucoma was based on glaucomatous visual-field defects with a mean deviation better than -12dB. All patients underwent imaging with Stratus optical coherence tomography. We subsequently performed analysis for macular volume and thickness parameters between two groups.
ResultsUsing Stratus optical coherence tomography, we found significantly lower values in both macular thickness and volume over outer superior, outer nasal, outer inferior, inner temporal and inner inferior regions in highly myopic eyes with early to moderate glaucoma than in the control group. The macular outer inferior average thickness, macular outer inferior average volume and total average macular volume on Stratus optical coherence tomography had a best combination of sensitivity and specificity (85.4 and 74.2 per cent, respectively). The outer inferior average volume and outer inferior average thickness parameters showed areas under the receiver operating characteristic curve value of 0.85 (95% CI 0.76 to 0.94), which were best for discriminating between early to moderate glaucoma and the control group.
ConclusionUsing Stratus optical coherence tomography, the outer inferior macular volume is the only independent predictor for detecting early to moderate glaucoma in high myopia. The macular outer inferior thickness and volume parameters showed good sensitivity, specificity and area under the receiver operating characteristic curve. These parameters may provide a complementary glaucomatous diagnosis in highly myopic eyes.

• 出版日期2015-1
• 单位中山大学; 长春大学