A new dicoumarin and anticoagulant activity from Viola yedoensis Makino

作者：Zhou Hai Yan; Hong Jun Li; Shu Pan; Ni Yue Juan; Qin Min Jian^*

来源：Fitoterapia, 2009, 80(5): 283-285.

DOI：10.1016/j.fitote.2009.03.005

• Viola yedoensis
• Dimeresculetin
• Euphorbetin
• Anticoagulant activity

A new dicoumarin, named as dimeresculetin (1), together with another dicoumarin, euphorbetin (2) and esculetin (3) were isolated from the ethyl acetate extract of the dried whole plants of Viola yedoensis Makino. The structure of I was elucidated as 7-hydroxy-6-[(6,7-dihydroxy-2-oxo-2H-1-benzopyran-5-yl)oxy]-2H-1-benzopyran-2-one on the basis of extensive NMR, as well as the other spectral analysis. Compounds 1-3 exhibited anticoagulant activities with respect to activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT).

• 出版日期2009-7
• 单位中国药科大学