科研之友
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摘要
In order to further improve the biocompatibility of xylitol based bioelastomer (PXS), glutamic acid was introduced into PXS and a novel kind of amino acid based bioelastomer (PXGS) has been prepared by melt polycondensation of xylitol, N-Boc glutamic acid and sebacic acid. DSC spectra indicate that there is a micro-phase separation structure originating from crystalline and amorphous regions in it. The properties of PXGS are easily tunable by altering the dosage of sebacic acid and crosslinking time, such as tensile strength between 0.17 and 2.67 MPa, elongation at break between 148% and 972%, water contact angle between 48 and 70. With the increase of the dicarboxylic acid content, the tensile strength of the elastomer increases; the increase of glutamic acid makes the elongation at break increase. The PXGS are facile biodegradable and the degredation rate could be controlled by changing the monomer ratios. PXGS are desired to be used as drug delivery carrier, scaffold material, anti-adhesion film after operation etc.
- 出版日期2014-9
- 单位江南大学
