A Pediatric Case of Peripheral Polyneuropathy With IgM anti-GM1 Antibody Associated With a Group A Beta-Hemolytic Streptococcus Infection

作者：Ishikawa Nobutsune^*; Kobayashi Yoshiyuki; Fujii Yuji; Samukawa Makoto; Kusunoki Susumu; Kobayashi Masao

来源：Pediatric Neurology, 2014, 51(3): 441-443.

DOI：10.1016/j.pediatrneurol.2014.03.019

• peripheral polyneuropathy
• childhood
• GABHS infection
• antiglycolipids antibody

INTRODUCTION: Postinfectious peripheral neuropathy can be associated with various viral or bacterial infections. Group A beta-hemolytic Streptococcus infection can lead to neurological disorders, which involve predominantly the central nervous system, whereas peripheral neuropathy during childhood is rare. PATIENT DESCRIPTION: We describe a 12-year-old boy who presented with peripheral polyneuropathy associated with Group A beta-hemolytic Streptococcus infection. Anti-GM1 IgM was significantly elevated in his serum during the acute phase, which suggested that it was related with the pathophysiology in this patient. CONCLUSION: Group A beta-hemolytic Streptococcus infection may cause peripheral neuropathy via the autoimmune system and glycolipids.

• 出版日期2014-9