Near-infrared conjugated polymers for photoacoustic imaging-guided photothermal/chemo combination therapy

作者：Cao, Yue; Wu, Yannan; Wang, Guannan; Yi, Jingwen; Yu, Chunlei; Huang, Yanxin; Sun, Luguo^*; Bao, Yongli^*; Li, Yuxin^*

来源：Journal of Materials Chemistry B, 2017, 5(27): 5479-5487.

DOI：10.1039/c7tb01264k

• VIVO CANCER-THERAPY
• IN-VIVO
• GOLD NANOPARTICLES
• ANTICANCER DRUGS
• DELIVERY
• AGENT
• CELLS
• NANOSPHERES
• ABLATION
• TUMORS

Conjugated polymers (CPs) with intensive near-infrared (NIR) absorption and high photothermal conversion efficiency (PCE) have emerged as a new generation of photothermal therapy (PTT) and photoacoustic imaging (PAI) agents for cancer therapy. PTT + chemotherapy has been identified as a powerful modality to offer synergistic effects in the destruction and monitoring of cancer tissues. In this study, diketopyrrolopyrrole-based polymers (DPP) were designed through a combination of donor-acceptor moieties. Then, doxorubicin (DOX) and DPP were co-encapsulated in tocopheryl polyethylene-glycolsuccinate-cholesterol (TPGS-CHO) copolymers to build a combined theranostic system for tumor treatment. These combined NPs with high PCE (similar to 50%) and strong (NIR) absorption exhibit excellent real-time photoacoustic imaging detection and synergistic cancer inhibition.

• 出版日期2017-7-21
• 单位东北师范大学