Mitochondrial diabetes: Clinical features, diagnosis and management

作者：Meas T^*; Laloi Michelin M; Virally M; Ambonville C; Kevorkian J P; Guillausseau P J

来源：Revue de Medecine Interne, 2010, 31(3): 216-221.

DOI：10.1016/j.revmed.2008.11.017

• MIDD
• Mitochondrial diabetes
• 3243A &gt
• G mtDNA mutation

Mitochondrial diabetes affects up to 1% of patients with diabetes and is often unrecognised by the physicians. Maternally inherited diabetes and deafness (MIDD) resulting from the mutation 3243A>G of the mitochondrial DNA is the most frequent mutation associated with mitochondrial diabetes. This review summarizes the range of clinical phenotypes associated with MIDD and outlines the advances in genetic diagnosis, pathogenesis and management of these patients.

• 出版日期2010-3